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Preparation registered in Ukraine
O.G. Gaponova
Vita-melatonin in the pathogenetic therapy of functional dyspepsia in overweight patients which forming an overburdening syndrome
62 overweight patients with functional dyspepsia were examined. They were divided into 2 equal groups: first of them was treated by standard therapy of functional dyspepsia; the second one was additionally managed by Vita-melatonin (made by Šublic corporation «Kyiv vitamin factory») in the dose of 3 mg taken by mouth 30 minutes prior to sleep time during 3 weeks. Urine 6-sulfatoxymelatonin, serum leptin and ghrelin levels were measured before and after treatment; patients were also assessed with the Gastrointestinal Symptom Rating Scale (GSRS), alexythymia, depression and anxiety scales. Additional management of Vita-melatoninresulted in significant improvement of clinical (decrease of total GSRS score) psychosomatic (decrease of alexythymia, depression and anxiety scores) and neurohormonal characteristics (increase of urine 6-sulfatoxymelatonin excretion and serum total ghrelin levels, decrease of serum leptin level) in comparison with standard therapy of functional dyspepsia. Vita-melatonin should be used as safety agent of pathogenetic therapy functional dyspepsia in overweight patients, who have an overburdening syndrome.
Keywords: 6-sulfatoksimelatonin, leptin, ghrelin, alexithymia, depression, trait anxiety, situational anxiety, Vita-melatonin.