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I.I. Lisnyy, M.V. Bondar
The choice of the dose melatonin for correcting sleep deprivation i surgical patients at the critical care unit. Double, blind, placebo controlled randomized study
The goal of this study was to define the efficient doses of melatonin for the correction of sleep deprivation in patients in adult ICU. Melatonin, hormone of the pineal gland is responsible for normal sleep regulation in mammalians. As consequence of strong external irritants severe patient in ICU have sleep deprivation, which render the negative influence upon current of the main severe disease and lengthen the duration of the treatment. The present study was established that melatonin in dose 9 mg at night for severe patients have improved the quality of sleep, possesses the stress protective effect, saves circadian secretion of Cortisol and doesn't interrupt the melatonin secretion.
Keywords: sleep deprivation, Cortisol, melatonin.